Angel City Bio

Angel City Bio has developed a drug delivery system that conjugates therapeutic small molecules to bile acids, enabling targeted and repeated cycling between the liver and intestine. This orally administered platform is designed to treat Crohn's disease without the use of immunosuppressive agents, offering a safer alternative to existing injectable therapies, particularly for mild-to-moderate cases. Its key differentiator lies in leveraging enterohepatic circulation (the movement of bile acid molecules from the liver to the small intestine and back to the liver) to enhance efficacy while minimizing systemic side effects, addressing a significant unmet need in the current treatment landscape.