Karine Rossignol

CEO & Co-Founder, Smart Immune

With more than 30 years of experience in the global biopharmaceutical industry and biomedical innovation, she has built a career at the intersection of science, entrepreneurship, and strategic leadership. As CEO and co-founder of Smart Immune, she leads the development of ProTcell, a pioneering T cell progenitor platform designed to restore immune function for patients with cancer and severe infections. Under her leadership, the company has advanced from groundbreaking science to clinical validation, successfully demonstrating the safety and therapeutic potential of its lead cell therapy candidate in patients with acute leukemia. Previously, she played a central role in building the Imagine Institute into a world leading center for genetic disease research and led the Fondation Pour l’Audition. Combining a Doctor of Pharmacy degree with business training from HEC Paris, she brings deep expertise in company building, translational medicine, fundraising, strategic partnerships, and transforming breakthrough science into impactful therapeutic innovations.